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Share the article Changes in the intestinal flora seem to play an important role in whether people in old age develop neurodegenerative diseases such as Alzheimer's or Parkinson's.The targeted modulation of the intestinal flora could therefore offer promising opportunities for prevention and treatment of neurodegenerative diseases. A research team, with the participation of experts from the University of Pennsylvania, analyzed the complex mutual signal paths between the intestinal flora and the brain and published the results in the specialist journal "Neural regeneration research". Darm & brain in constant exchange For some years now, the indications that communication between intestinal bacteria and the brain can influence health has been increasing, the research team reports. It is also known that the composition of the intestinal flora changes with increasing age and these changes play an important role in the development of many neurodegenerative diseases. Darmflora influences neurodegenerative diseases The intestinal flora and its metabolites have a decisive influence on the regulation of inflammation, the preservation of intestinal health and the development of neurodegenerative diseases such as Alzheimer's, Parkinson and amyotrophic lateral sclerosis, the researchers continue. According to the experts, the intestinal microbiota have an effect on the brain, in particular through the production of important metabolites such as short -chain fatty acids and the activation of important signal pathways for inflammation. Reduction of pathological processes in the nervous system Last but not least, animal models have already managed to relieve behavioral problems through a targeted modulation of the intestinal flora (e.g. prebiotics or probiotics) and to weaken pathological processes in the nervous system. Read too: Treatments based on the intestinal flora could therefore have great potential for diseases of the nervous system, even if further research is necessary to carefully examine the safety and effectiveness of such therapies.Because the intestinal flora is high and interventions could cause unexpected side effects. Regardless of further research results, however, it is sufficiently proven that a high -fiber diet with lots of vegetables, fruit and whole grains promotes the variety of intestinal flora and increases the presence of healthy bacteria.According to the new study, this in turn can also counteract neurodegenerative diseases.(as)